| 产品详情 |
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| Antigenic Specificity | Phospho-INSR (Tyr1158) |
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| Clone | 8H20L22 |
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| Host Species | Recombinant Rabbit |
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| Reactive Species | human |
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| Isotype | IgG |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot: 1-3 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-INSR (Tyr1158) Antibody (8H20L22), ABfinity™ Rabbit Monoclonal. INSR (insulin receptor, IR) is a heterodimeric protein complex that has an intracellular beta subunit and an extracellular alpha subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular r |
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| Immunogen | n/a |
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| Other Names | CD220, HHF5, insulin receptor, INSR, CD221, IGF-I receptor, insulin-like growth factor I receptor, soluble IGF1R variant 1, soluble IGF1R variant 2 |
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| Gene, Accession # | Entrez: 3643; Uniprot: P06213 |
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| Catalog # | 701070 |
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| Price | |
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| Order / More Info | Phospho-INSR (Tyr1158) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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