| 产品详情 |
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| Antigenic Specificity | Phospho-IRAK1 (Ser376) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:50-1:100 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-IRAK1 (Ser376) Polyclonal Antibody. Interleukin-1 receptor-associated kinase 1 (IRAK1) is a serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. IRAK is associated with Toll-like receptor (TLR) and IL-1R signaling pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK's association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. Th |
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| Immunogen | n/a |
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| Other Names | IL-1 Receceptor Associated Kinase, Interleukin-1 receptor-associated kinase 1, mPLK, IRAK, pelle, Pelle homolog, Pelle |
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| Gene, Accession # | Entrez: 3654; Uniprot: P51617 |
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| Catalog # | PA5-37611 |
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| Price | |
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| Order / More Info | Phospho-IRAK1 (Ser376) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 产品资料 |
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