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| Antigenic Specificity | Phospho-IR/IGF1R (Tyr1158) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:100-1:500, Immunofluorescence: 1:100-1:500, Immunohistochemistry: Assay Dependent, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-IR/IGF1R (Tyr1158) Polyclonal Antibody. Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptors, both of which are receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The IR and IGF-1R are heterotetrameric proteins consisting of two ligand-binding alpha subunits, which are completely extracellular, and two beta subunits that span the membrane with an intracellular portion that each contain a tyrosine kinase domain. These disulfide-linked subunits are in a beta-alpha-alpha-beta configuration in the mature receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of the receptor and activat |
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| Immunogen | n/a |
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| Other Names | IGF1 Receptor, IGF-I Receptor, IGF1R, CD221, IGFIR, IGFR, JTK13, IGF-I receptor, insulin-like growth factor I receptor, soluble IGF1R variant 1, soluble IGF1R variant 2, CD220, HHF5, INSR, Insulin receptor |
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| Gene, Accession # | Entrez: 3480, 3643; Uniprot: P06213, P08069 |
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| Catalog # | 44-802G |
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| Order / More Info | Phospho-IR/IGF1R (Tyr1158) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 15563471, 16037382, 17500057, 24935677, 27155325, 27797911 |
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