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| Product Name | gamma-Secretase Inhibitor XXV, FT-9 (2-[3-(3,5-dichlorophenoxy)phenyl]propanoic Acid) |
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| Description | Purity ~97% (HPLC). FT-9, a cell-permeable NSAID-like compound, is a partially selective gamma-Secretase Inhibitor in both microsomes and whole cells. Displays dose-dependent inhibition of the gamma-secretase cleavage of beta-Amyloid Precursor Protein (APP) and APLP2 with IC50 values against APP ICD (intracellular domain) and APLP2 ICD of ?260uM, but there is a less potent effect on gamma-secretase processing of APLP1. The concentration of FT-9 required to cause a 2-fold increase in APP CTFs, 3.4 +/- 0.4uM, is significantly lower than that for APLP1 (25.7 +/- 8.9uM) (P = 0.001). For comparison, the concentration of another gamma-Secretase inhibitor compound E needed for a 2-fold increase in the magnitude of the CTF band signal is not significantly different, being 0.27nM for APP versus 0.24nM for APLP1. This is the first example that a GSI can preferentially target APP processing while sparing other gamma-substrates. Formula: C15H12Cl2O3 Solubility: DMSO Molar Mass: 311.2 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217786 |
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| Order / More Info | gamma-Secretase Inhibitor XXV, FT-9 (2-[3-(3,5-dichlorophenoxy)phenyl]propanoic Acid) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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