| 产品详情 |
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| Antigenic Specificity | RIC8A |
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| Clone | OTI3G3 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:100, Immunofluorescence: 1:100, Immunohistochemistry (Paraffin): 1:50, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | RIC8A Monoclonal Antibody (OTI3G3). Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. |
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| Immunogen | n/a |
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| Other Names | RIC8A; synembryn; resistance to inhibitors of cholinesterase 8 homolog A (C. elegans); MGC104517; MGC131931; RIC8; RIC8 protein; resistance to inhibitors of cholinesterase 8 homolog A; MGC148073; MGC148074 |
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| Gene, Accession # | Entrez: 60626; Uniprot: Q9NPQ8 |
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| Catalog # | MA5-25075 |
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| Price | |
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| Order / More Info | RIC8A Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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