| 产品详情 |
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| Antigenic Specificity | Phospho-IRS1 (Tyr612) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-IRS1 (Tyr612) Polyclonal Antibody. Insulin receptor substrates (IRS) are responsible for several insulin-related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis, and insulin signal transduction. IRS-1 is a multi-phosphorylated cytoplasmic docking protein involved in the positive regulation of metabolism and proliferation by insulin, IL-4, and other cytokines. The catalytic domain of the insulin receptor is activated upon binding extracellular binding of ligand, resulting in cytoplasmic binding of IRS proteins. IRS is phosphorylated on tyrosine residues, to recruit a variety of Src homology-2 (SH2) domain-containing proteins and activate PI3-kinase, and MAP kinase signaling pathways. When phosphor |
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| Immunogen | n/a |
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| Other Names | IRS-1, IRS1, Insulin receptor substrate-1 |
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| Gene, Accession # | Entrez: 3667; Uniprot: P35568 |
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| Catalog # | 44-816G |
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| Price | |
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| Order / More Info | Phospho-IRS1 (Tyr612) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 18022157, 19258508, 20924128, 21127070, 21177763, 22275362, 23142819, 23838844, 24084737, 24261972, 24386513, 25256746, 25383313, 25483727, 25594415, 25811318, 26100015, 26297026, 27243589, 27882346 |
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