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| Antigenic Specificity | Phospho-JAK1 (Tyr1022, Tyr1023) |
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| Clone | 59H4L5 |
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| Host Species | Recombinant Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | IgG |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | ChIP assay: 1 µL, Immunocytochemistry: 1:100-1:500, Immunofluorescence: 1:100-1:500, Western Blot: 0.5-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-JAK1 (Tyr1022, Tyr1023) Antibody (59H4L5), ABfinity™ Rabbit Monoclonal. Janus Kinase 1 leads to an association of those receptors with JAK proteins, which are then activated via phosphorylation of tyrosine residues in the kinase activation loop. Activated JAK proteins phosphorylate and activate STAT (signal transducers and activators of transcription) proteins, which then dimerize and translocate to the nucleus. Once in the nucleus, STAT proteins bind to DNA and modify the transcription of various genes, which can lead to various responses such as cell proliferation, cell survival and differentiation. |
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| Immunogen | n/a |
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| Other Names | JAK1A, JAK1B, JTK3, tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK1, Janus kinase 1 |
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| Gene, Accession # | Entrez: 16451, 3716; Uniprot: P23458, P52332 |
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| Catalog # | 700028 |
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| Price | |
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| Order / More Info | Phospho-JAK1 (Tyr1022, Tyr1023) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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