| 产品详情 |
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| Antigenic Specificity | GAPVD1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1-4 µg/mL, Immunofluorescence: 1-4 µg/mL, Immunohistochemistry: 1:50-1:200, Western Blot: 0.4 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | GAPVD1 Polyclonal Antibody. GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and deg |
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| Immunogen | n/a |
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| Other Names | GTPase activating protein and VPS9 domains 1, DKFZP434C212, KIAA1521, MGC138847, MGC138848, RAP6, GAPEX5 |
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| Gene, Accession # | Entrez: 26130, 311880, 66691; Uniprot: Q14C86, Q6PAR5 |
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| Catalog # | PA5-56123 |
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| Price | |
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| Order / More Info | GAPVD1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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