| 产品详情 |
| Edit |   |
|---|
| Product Name | Alpha-Hydroxyglutaric Acid (sodium salt) |
|---|
| Description | Purity >95%. Alpha-Hydroxyglutaric acid (2-HG) is an Alpha-hydroxy acid. It is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenases 1 and 2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than Alpha-ketoglutarate. 2-HG is structurally similar to Alpha-ketoglutarate and competitively inhibits Alpha-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 2-hydroxy-pentanedioic acid, disodium salt, 2-HG, 2-Hydroxyglutaric Acid |
|---|
| Gene, Accession, CAS # | CAS: 40951-21-1 |
|---|
| Catalog # | LS-H10605 |
|---|
| Price | |
|---|
| Order / More Info | Alpha-Hydroxyglutaric Acid (sodium salt) from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|