| 产品详情 |
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| Antigenic Specificity | CD221 (IGF1R) |
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| Clone | 1H7 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, kappa |
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| Format | Alexa Fluor 488 conjugate |
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| Size | 100 Tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 5 µL (0.5 µg)/test |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD221 (IGF1R) Monoclonal Antibody (1H7), Alexa Fluor 488, eBioscience™. Insulin growth factor 1 receptor belongs to the family of tyrosine receptor kinases. It is involved in activation of various substrates including IGF and neurotensin, regulation of metabolism, cell division, maintenance, and inflammation response. The protein is a tetramer consisting of two alpha, and two beta subunits. The alpha-subunits binds to insulin growth factor 1 with higher affinity than to insulin growth factor 2. Binding results in a conformational change, followed by autophosphorylation of IGF-1R at positions 1134, 1135, 1136. The activated IGF-1R in turn, causes phosphorylation of substrate proteins, followed by sequential activation of RAS, RAF, and |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | Entrez: 3480; Uniprot: P08069 |
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| Catalog # | 53-8849-42 |
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| Price | |
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| Order / More Info | CD221 (IGF1R) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 24298236 |
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