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| Product Name | NCT-501 (hydrochoride) |
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| Description | Purity >98%. Aldehyde dehydrogenases (ALDHs) catalyze the NAD(P)+ -dependent oxidation of aldehyde-containing substrates to the corresponding carboxylic acids. ALDH1A1 activity is elevated in certain stem cells and cancers. NCT-501 is a potent, reversible, theophylline-based inhibitor of ALDH1A1 (IC50 = 40 nM for the human form). It is selective for ALDH1A1 over other ALDH isozymes as well as other dehydrogenases. Pharmacokinetic studies indicate that NCT-501 has high bioavailability when delivered intraperitoneally, with rapid phase I modification in the liver. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-1H-purine-2,6-dione, monohydrochloride |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H8935 |
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| Price | |
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| Order / More Info | NCT-501 (hydrochoride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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