| 产品详情 |
| Edit |   |
|---|
| Product Name | Human TNFRSF14 / CD270 / HVEM Protein (Recombinant) |
|---|
| Description | MW: ~45 kDa (SDS-PAGE). Herpes Virus Entry Mediator (HVEM) is a transmembrane protein that is the receptor for TNFSF14 (also known as LIGHT) and is therefore referred to asTNFRSF14. HVEM is expressed broadly on immune cells such as T cells, natural killer (NK) cells and monocytes. The interaction of 3 molecules of LIGHT with three molecules of HVEM forms a hexameric complex that leads to the recruitment and retention of effector cells and activates NK cells to produce large amounts of IFN-gamma and GM-CSF. In addition to the canonical binding partner LIGHT, HVEM can also bind to the inhibitory signaling protein, B- and T- lymphocyte attenuator (BTLA),which suppresses immune responses. Therefore, the HVEM network plays an important role in regulating immunity and the behavior of lymphocytes.Recombinant human HVEM-Fc (rhHVEM-Fc) produced in Sf9 insect cells is a single glycosylated polypeptide chain containing 376 amino acids. A fully biologically active molecule, rhHVEM-Fc has a molecular mass of around 45 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | TNFRSF14, CD270, CD270 antigen, CD40-like protein, Herpesvirus entry mediator, Herpesvirus entry mediator A, HVEM, LIGHTR, Herpes virus entry mediator A, TR2, ATAR, HVEA |
|---|
| Gene, Accession, CAS # | TNFRSF14, Gene ID: 8764 |
|---|
| Catalog # | LS-G27259 |
|---|
| Price | |
|---|
| Order / More Info | Human TNFRSF14 / CD270 / HVEM Protein (Recombinant) from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|