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| Product Name | CDK4/CyclinD1, Recombinant, Human, GST-tag |
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| Description | Purified (~70-90%). CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of RB protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Source: Recombinant protein corresponding to human CDK4/CyclinD1, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~57kD, 61kD Specific Activity: 12nmol/min/mg as per activity assay protocol using protein substrate Rb (773-928). Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CDK4/CyclinD1, Recombinant, Human, GST-Tag (CDK4: CMM3, PSK-J3, MGC14458 CyclinD1: BCL1, PRAD1, U21B31, D11S287E) |
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| Gene, Accession, CAS # | Accession: NM_000075 |
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| Catalog # | 499872 |
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| Order / More Info | CDK4/CyclinD1, Recombinant, Human, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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