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| Product Name | 3,5-dimethyl PIT-1 |
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| Description | Purity >98%. PtdIns-(3,4,5)-P3 (PIP3 ) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer. 3,5-dimethyl PIT-1 is a dimethyl analog of PIT-1, the selective inhibitor of PIP3 /Akt PH domain binding, that is designed for more favorable solubility in vivo . 3,5-dimethyl PIT-1 inhibits PI3K/Akt signaling (IC50 = 27 µM), suppressing PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 36 µM). 4T1 breast cancer growth is significantly attenuated in BALB/c mice with a dose of 1 mg/kg of 3,5-dimethyl PIT-1 per day. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[[(2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-3,5-dimethyl-benzamide |
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| Gene, Accession, CAS # | CAS: 701947-53-7 |
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| Catalog # | LS-H6032 |
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| Order / More Info | 3,5-dimethyl PIT-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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