| 产品详情 |
| Edit |   |
|---|
| Product Name | EGFR, Recombinant, Human |
|---|
| Description | Purity ~95% (SDS-PAGE and HPLC). EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including TGF, HB-EGF, Betacellulin (BTC), Amphiregulin, Epiregulin, and Epigen. Upon activation, EGFR initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers. Recombinant soluble human EGFR is a 621aa glycoprotein comprising the extracellular domain of EGFR, and migrates at an apparent MW of 97.5kD by SDS-PAGE analysis under reducing conditions. Source: Recombinant protein corresponding to human EGF Receptor, expressed in CHO cells. Endotoxin: <0.1 |
|---|
| Size | 2ug, 10ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | EGFR, Recombinant, Human (Epidermal Growth Factor Receptor, Proto-oncogene c-ErbB-1, Receptor Tyrosine-protein Kinase erbB-1, ERBB, ERBB1, HER1) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 149742 |
|---|
| Price | |
|---|
| Order / More Info | EGFR, Recombinant, Human from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|