| 产品详情 |
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| Product Name | Recombinant Human Rho guanine nucleotide exchange factor 18 (ARHGEF18), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 71.5kDa. Partial: 159-551aa. N-terminal GST-tagged. Homo sapiens (Human). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | 114KDA Rho-specific guanine nucleotide exchange factor; p114-Rho-GEF; p114RhoGEFSeptin-associated RhoGEF; SA-RhoGEF |
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| Gene, Accession, CAS # | ARHGEF18, UniProt: Q6ZSZ5 |
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| Catalog # | RPC24084 |
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| Price | |
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| Order / More Info | Recombinant Human Rho guanine nucleotide exchange factor 18 (ARHGEF18), partial from BIOMATIK |
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| Product Specific References | n/a |
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