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| Product Name | IL-1F8, Recombinant, Mouse, aa31-183 |
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| Description | Purity ~95% (SDS-PAGE). Mouse interleukin-36 beta [IL-36B; previously IL-1F8, FIL-1H (eta) and IL-1H2] is a member of the IL-1 family of proteins that includes IL-1B, IL-1A, IL-1ra, IL-18, IL-36Ra/IL-1F5, IL-36A/IL-1F6, IL-37/IL-1F7, IL-36G/IL-1F9 and IL-1F10. All family members show a 12 B-stranded B-trefoil configuration, share up to 50% aa sequence identity, and are believed to have arisen from a common ancestral gene. Although two alternatively spliced transcript variants for human IL-36B/IL-1F8 have been described, to date, only one mouse IL-36B/IL-1F8 isoform is known. Mouse IL-36B/IL-1F8 is synthesized as a 183aa protein that contains no signal sequence, no prosegment and no potential N-linked glycosylation site(s). Mouse IL-36B/IL-1F8 shares 61% and 74% aa identity with human IL-36B isoform 2 and rat IL-36B, respectively. IL-36B is agonistic, stimulating release of inflammatory mediators such as IL-6 and IL-8, and cytotoxic peptides such as beta-defensins 2 and 3 that aid in de |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL-1F8, Recombinant, Mouse, aa31-183 (IL-36 beta, Interleukin-36 beta, Interleukin-1 Family Member 8, Il36b, Fil1e, Il1f8) |
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| Gene, Accession, CAS # | SwissProt: Q9D6Z6 |
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| Catalog # | I7663-24Y |
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| Order / More Info | IL-1F8, Recombinant, Mouse, aa31-183 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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