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| Antigenic Specificity | Lck Interacting Transmembrane Adaptor 1 (LIME1) (aa 141-295) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 0.1 mg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals. |
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| Immunogen | Bacterially expressed intracellular fragment corresponding to aa 141-295 of human LIME. |
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| Other Names | LIME1|DKFZp459A158|LIME|LP8067|dJ583P15.4|2810038K19Rik|RGD1562795 |
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| Gene, Accession # | Gene ID: 54923 |
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| Catalog # | ABIN94499 |
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| Price | |
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| Order / More Info | Lck Interacting Transmembrane Adaptor 1 (LIME1) (aa 141-295) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 14610046, 15582487, 15286727, 16160011 |
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