| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | T4S20 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | canine, human, rabbit, rat |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 µl |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blot: 0.2-1.0 µg/mL |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | T4S20 Polyclonal Antibody. Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293). |
|---|
| Immunogen | n/a |
|---|
| Other Names | PRO994; TCCE518; transmembrane 4 L6 family member 20 |
|---|
| Gene, Accession # | Entrez: 100340913, 609780, 691066, 79853; Uniprot: Q53R12 |
|---|
| Catalog # | PA5-69644 |
|---|
| Price | |
|---|
| Order / More Info | T4S20 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|