| 产品详情 |
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| Antigenic Specificity | TS |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1:50-1:200, Western Blot: 1:1,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | TS Polyclonal Antibody. Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas. |
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| Immunogen | n/a |
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| Other Names | HST422, MGC88736, TMS, TS |
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| Gene, Accession # | Entrez: 22171, 7298; Uniprot: P04818, P07607 |
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| Catalog # | A304-000A-M |
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| Price | |
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| Order / More Info | TS Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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