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| Product Name | NVP-TNKS656 |
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| Description | Purity >98%. NVP-TNKS656 is an orally bioavailable inhibitor of tankyrase 2 (TNKS2; IC50 = 6 nM). It is selective for TNKS2 over poly(ADP-ribose) polymerase (PARP) 1 and 2 (IC50 s = >19 and 32 nM, respectively). NVP-TNKS656 inhibits Wnt ligand-induced signaling with an IC50 value of 3.5 nM in an HEK293 cell reporter assay. In vivo, NVP-TNKS656 (350 mg/kg) reduces Axin 2 mRNA expression, a Wnt/Beta-catenin target gene, in MMTV-Wnt1 tumor bearing mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-1-piperidineacetamide |
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| Gene, Accession, CAS # | CAS: 1419949-20-4 |
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| Catalog # | LS-H9120 |
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| Order / More Info | NVP-TNKS656 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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