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| Product Name | Curcubitacin E |
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| Description | Purity >98% by HPLC. Curcubitacin E is a potent actin depolymerization inhibitor. Shown to have a different mechanism of action compared to Jasplakinolide, binding to a different site. Binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, stabilizing F-actin without affecting actin polymerization or nucleation. Does not bind to monomeric actin (G-actin). Acts as an immunomodulator with anti-inflammatory and anti-tumorigenic properties in a range of cancer cell lines, mediated by its action on the cellular cytoskeleton, on mitotic pathways as well as on cellular autophagy. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | BRN2343323, Cuc E, NSC106399, A-Elaterin, A-Elaterine |
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| Gene, Accession, CAS # | CAS: 18444-66-1 |
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| Catalog # | LS-H4129 |
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| Order / More Info | Curcubitacin E from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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