| 产品详情 |
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| Product Name | NVP-231 |
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| Description | Purity >98%. Ceramides have diverse roles in cell differentiation, proliferation, and apoptosis. Ceramide kinase converts ceramide to ceramide-1-phosphate (C1P), removing the effects of ceramide in favor of those directed by C1P. NVP-231 is a potent, reversible inhibitor of ceramide kinase (IC50 = 12 nM). It has minimal effect on several other lipid kinases, including sphingosine kinases 1 and 2. In cells in which exogenous short chain ceramide is converted to C1P, resulting in cell death, NVP-231 prevents both C1P synthesis and cell death. In mouse dermal microvascular endothelial cells, where ceramide kinase increases capillary-like tube formation, NVP-231 (100 nM) inhibits C1P formation as well as tube formation. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[2-(benzoylamino)-6-benzothiazolyl]-tricyclo[3.3.1.13,7]decane-1-carboxamide |
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| Gene, Accession, CAS # | CAS: 362003-83-6 |
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| Catalog # | LS-H9108 |
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| Order / More Info | NVP-231 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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