| 产品详情 |
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| Product Name | BQ-788 (sodium salt) |
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| Description | Purity >95%. The endothelin (ET) family of proteins mediate a variety of responses, with ET-1 being a potent and long-lasting constrictor of human cardiovascular vessels. These proteins activate the G protein-coupled receptors ETA and ETB, with ETB being non-specific for ET protein form. BQ-788 is a potent, selective antagonist of ETB (IC50 = 1.2 nM for blocking ET-1 binding to human Girardi heart cells). It weakly inhibits the binding of ET-1 to ETA receptors on human neuroblastoma SK-N-MC cells (IC50 = 1300 nM). BQ-788 competitively antagonizes the vasoconstriction induced by an ETB -selective agonist on isolated rabbit pulmonary arteries, blocks ET-1 induced bronchoconstriction in guinea pigs, and abolishes an ET-1 mediated depressor response in rats. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine, monosodium salt |
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| Gene, Accession, CAS # | CAS: 156161-89-6 |
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| Catalog # | LS-H6881 |
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| Order / More Info | BQ-788 (sodium salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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