| 产品详情 |
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| Product Name | SR 1555 (hydrochloride) |
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| Description | Purity >97%. Retinoic acid receptor-related nuclear receptor gamma (ROR gamma) plays a central role in T cell differentiation, particularly in the development of TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis. SR 1555 is a selective ligand of ROR gamma (IC50 = 1 µM). It does not bind ROR alpha, LXR, or FXR. SR 1555 acts as an inverse agonist of ROR gamma, inhibiting endogenous IL-17A gene expression in mouse splenocytes and suppressing differentiation of TH17 cells when cultured under TH17 polarizing conditions. Moreover, SR 1555 stimulates T regulatory development when cultured under T regulatory polarizing conditions, unlike digoxin and ursolic acid. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethanone, monohydrochloride |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H84 |
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| Price | |
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| Order / More Info | SR 1555 (hydrochloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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