| 产品详情 |
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| Product Name | Recombinant Human Proteasome activator complex subunit 3 (PSME3), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 56.1kDa. Partial: 2-252aa. N-terminal GST-tagged. Homo sapiens (Human). Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | 11S regulator complex subunit gamma; REG-gammaActivator of multicatalytic protease subunit 3Ki nuclear autoantigen; Proteasome activator 28 subunit gamma; PA28g; PA28gamma |
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| Gene, Accession, CAS # | PSME3, UniProt: P61289 |
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| Catalog # | RPC24310 |
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| Price | |
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| Order / More Info | Recombinant Human Proteasome activator complex subunit 3 (PSME3), partial from BIOMATIK |
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| Product Specific References | n/a |
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