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| Product Name | Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-286) protein (His tag) |
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| Description | Cytotoxic and Regulatory T-Cell Molecule (CRTAM) is a member of Nectin family under the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and it is highly expressed by Purkinje cells of the cerebellum. CRTAM is a type I transmembrane glycoprotein containing one Ig-like C2-type domain and one Ig-like V-type domain in its extracellular domain, while its cytoplasmic region shows a potential class I PDZ domain. CRTAM is expressed as a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor coengagement of CD8+ cells expressiong CRTAM induces increased IFNgamma or IL-22 production.Alternative Names: Cytotoxic and Regulatory T-Cell Molecule, Class-I MHC-Restricted T-Cell-Associated Molecule, CD355, CRTAM |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TAD|cTADS|MGC82176|CRTAM|CD355 |
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| Gene, Accession, CAS # | Gene ID: 56253 |
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| Catalog # | ABIN1096450 |
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| Order / More Info | Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-286) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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