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| Product Name | Recombinant Human Histone H2AX (H2AFX), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 17.8kDa. Partial: 12-141aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Histone H2A.X |
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| Gene, Accession, CAS # | H2AFX,H2AX, UniProt: P16104 |
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| Catalog # | RPC24357 |
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| Order / More Info | Recombinant Human Histone H2AX (H2AFX), partial from BIOMATIK |
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| Product Specific References | n/a |
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