| 产品详情 |
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| Antigenic Specificity | SIPA1L1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1-4 µg/mL, Immunofluorescence: 1-4 µg/mL, Immunohistochemistry: 1:20-1:50 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SIPA1L1 Polyclonal Antibody. Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation. |
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| Immunogen | n/a |
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| Other Names | E6TP1; E6-targeted protein 1; H_DJ1140G11.1; SIPA1-like protein 1; WUGSC:H_DJ1140G11.1; high-risk human papilloma viruses E6 oncoproteins targeted protein 1; signal-induced proliferation-associated 1-like 1; signal-induced proliferation-associated 1-like protein 1 |
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| Gene, Accession # | Entrez: 26037; Uniprot: O43166 |
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| Catalog # | PA5-51761 |
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| Price | |
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| Order / More Info | SIPA1L1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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