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| Product Name | SCH 900776 |
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| Description | Purity >95%. Checkpoint kinase 1 (Chk1) regulates S and G2 -M phase cell cycle checkpoints in response to DNA damage. SCH 900776 is a functionally selective inhibitor of Chk1 (Kd = 2 nM; IC50 = 3 nM). In comparison, 18-fold and 500-fold higher concentrations of this compound are required to inhibit CDK2 and Chk2. At 5-50 mg/kg, SCH 900776 dose-dependently interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinyl-pyrazolo[1,5-a]pyrimidin-7-amine, MK-8776 |
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| Gene, Accession, CAS # | CAS: 891494-63-6 |
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| Catalog # | LS-H9880 |
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| Order / More Info | SCH 900776 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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