| 产品详情 |
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| Antigenic Specificity | Feline IL4 |
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| Clone | 260749 |
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| Host Species | Mouse |
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| Reactive Species | feline |
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| Isotype | IgG2a |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA(Cap), WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Mouse Anti-Feline IL4 monoclonal antibody for ELISA(Cap), WB. Interleukin-4 (IL-4), also known as B cell-stimulatory factor-1, is a monomeric, approximately 13-18 kDa Th2 cytokine that shows pleiotropic effects during immune responses. It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four alpha-helix structure. Feline IL-4 is synthesized with a 24 amino acid (aa) signal sequence. Mature feline IL-4 shares 81%, 64%, 49%, 40%, and 40% aa sequence identity with canine, bovine, human, mouse, and rat IL-4, respectively. Human IL-4 is active on feline dendritic cells. IL-4 exerts its effects through two receptor complexes. The type I receptor, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R alpha and the common gamma chain (a shared subunit of the receptors for IL-2,-7,-9,-15, and-21). The type II receptor on nonhematopoietic cells consists of IL-4 R alpha and IL-13 R alpha 1. The type II receptor also transduces IL-13 mediated signals. IL-4 is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgE in B cells, acquisition of the Th2 phenotype by naive CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL-4 plays a dominant role in the development of allergic inflammation and asthma. |
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| Immunogen | Recombinant Protein |
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| Other Names | n/a |
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| Gene, Accession # | UniProt: P55030 |
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| Catalog # | CABT-L153 |
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| Price | |
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| Order / More Info | Feline IL4 Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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