| 产品详情 |
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| Product Name | CGP 57380 |
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| Description | Purity >94%. CGP 57380 is a selective inhibitor of MAP kinase-interacting kinase 1 (MNK1) in vitro (IC50 = 2.2 µM), with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. It blocks the phosphorylation of eIF4E in response to TNF- alpha, arsenite, anisomycin, PMA, or fetal calf serum in 293 cells (IC50 = 3 µM). CGP 57380 also dose-dependently inhibits TNF- alpha production in RAW 264.7 cells that have been co-treated with agonists for Toll-like receptor (TLR)2 (HKLM), TLR4 (LPS), TLR6/2 (FSL), TLR7 (imiquimod), or TLR9 (CpG DNA), presumably by inhibiting MNK1. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine, MNK1 Inhibitor |
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| Gene, Accession, CAS # | CAS: 522629-08-9 |
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| Catalog # | LS-H90 |
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| Price | |
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| Order / More Info | CGP 57380 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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