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| Product Name | 10058-F4 |
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| Description | Purity >95%. The Myc proto-oncogenes interact with Max to form a dimer that regulates gene transcription. The protein c-Myc, in particular, promotes gene expression relevant to cell growth and thus drives cancer. 10058-F4 is a cell-permeable thiazolidinone that inhibits the dimerization of c-Myc and Max at 64 µM, preventing c-Myc-dependent gene expression and cell proliferation. It induces cell cycle arrest, apoptosis, and myeloid differentiation at 100 µM in human acute myeloid leukemia cells. 10058-F4 is rapidly metabolized in mice when given intravenously, limiting its effects on tumors in vivo . In addition to c-Myc, 10058-F4 inhibits the nuclear Myc protein, N-Myc, at 50 µM, inducing arrest, apoptosis, and differentiation in neuroblastoma cells overexpressing the gene for N-Myc. This compound can be used to delineate novel actions of Myc proteins, especially those related to lipid and glucose metabolism. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-[(4-ethylphenyl)methylene]-2-thioxo-4-thiazolidinone |
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| Gene, Accession, CAS # | CAS: 403811-55-2 |
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| Catalog # | LS-H5760 |
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| Order / More Info | 10058-F4 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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