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| Antigenic Specificity | LRRFIP2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | equine, human, nonhuman primate |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 5 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LRRFIP2 Polyclonal Antibody. Leucine-rich repeat flightless-interacting protein 2 (LRRFIP2) belongs to the LRRFIP family. LRRFIP2 has multifaceted functions in innate immunity, apoptosis and development. LRRFIP2 can bind to MyD88 and positively regulate TLR activity as measured by NF-kB activity and cytokine production in macrophages. LPS stimulation also increases LRRFIP2 expression in macrophages. By interacting with Dvl, LRRFIP2 increases the cellular levels of β-catenin and activate β-catenin/LEF/TCF-dependent transcriptional activity. A dominant negative form of LRRFIP2 suppresses ectopic Wnt signaling in Xenopus embryos and partially inhibits endogenous dorsal axis formation. LRRFIP2 also interacts with Caspase-11 through Fl |
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| Immunogen | n/a |
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| Other Names | HUFI-2, LRR FLII-interacting protein 2, leucine-rich repeat flightless-interacting protein 2 |
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| Gene, Accession # | Entrez: 100050285, 9209; Uniprot: Q9Y608 |
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| Catalog # | PA5-23458 |
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| Price | |
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| Order / More Info | LRRFIP2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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