| 产品详情 |
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| Product Name | Chaetocin |
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| Description | Purity >95%. The methylation of histones by histone methyltransferases (HMT) is an important mechanism by which gene expression is stably altered during cellular differentiation and embryonic development. Chaetocin is a fungal mycotoxin that inhibits the HMT SU(VAR)3-9 (IC50 = 0.8 µM). It inhibits other Lys9-specific HMTs, including G9a (IC50 = 2.5 µM) and DIM5 (IC50 = 3 µM). Selectivity for Lys9-HMTs is indicated by higher IC50 values (>90 µM) for Lys20-specific PRSET7, Lys27-specific EZH2, and Lys4-specific SET7/9. Chaetocin potently induces cellular oxidative stress, selectively killing cancer cells and rapidly-proliferating primary cells. Chaetocin's effects on oxidative stress are, at least in part, due to its capacity to act as a competitive and selective substrate for thioredoxin reductase-1 (Km = 4.6 µM). Chaetocin is useful both in epigenetic studies as an HMT inhibitor and in cancer research. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2,2',3S,3'S,5aR,5'aR,6,6'-octahydro-3,3'-bis (hydroxymethyl)-2,2'-dimethyl-[10bR,10'bR(11aS,11'aS)-bi-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone |
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| Gene, Accession, CAS # | CAS: 28097-03-2 |
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| Catalog # | LS-H7101 |
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| Order / More Info | Chaetocin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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