| 产品详情 |
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| Antigenic Specificity | MSH2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 10 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1:100-1:500 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MSH2 Polyclonal Antibody. Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC). CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations. These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired. Microsatellites/simple repeatative sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurance of HPNCC. hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutSbeta, which binds to insertion/deletion loops in DNA. |
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| Immunogen | n/a |
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| Other Names | COCA1, FCC1, HNPCC, HNPCC1 |
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| Gene, Accession # | Entrez: 17685, 4436; Uniprot: P43246, P43247 |
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| Catalog # | IHC-00082-T |
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| Price | |
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| Order / More Info | MSH2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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