| 产品详情 |
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| Antigenic Specificity | MSH3 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:500-1:3000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MSH3 Polyclonal Antibody. Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. |
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| Immunogen | n/a |
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| Other Names | DUP, MRP1, DNA mismatch repair protein Msh3, divergent upstream protein, hMSH3, mismatch repair protein 1 |
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| Gene, Accession # | Entrez: 4437; Uniprot: P20585 |
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| Catalog # | PA5-27864 |
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| Price | |
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| Order / More Info | MSH3 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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