| 产品详情 |
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| Antigenic Specificity | MSH6 |
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| Clone | 44 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 6 mL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): Assay Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MSH6 Monoclonal Antibody (44). Defects in MSH6 are a cause of hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. it is characterized by a familial predisposition to early onset colorectal carcinoma (crc) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world. MSH6 is central to mismatch DNA repair. |
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| Immunogen | n/a |
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| Other Names | DNA mismatch repair protein Msh6, hMSH6, G/T mismatch-binding protein, GTBP, GTMBP, MutS-alpha 160 kDa subunit, p160, MSH6, GTBP |
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| Gene, Accession # | Entrez: 2956; Uniprot: P52701 |
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| Catalog # | 08-1374 |
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| Price | |
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| Order / More Info | MSH6 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 18254781, 19275958, 19821155, 21733559, 24533633 |
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