| 产品详情 |
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| Antigenic Specificity | p53 |
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| Clone | cocktail |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rhesus monkey |
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| Isotype | IgG2a/IgG2b |
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| Format | purified |
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| Size | 500 µL |
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| Concentration | n/a |
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| Applications | ChIP assay: 1-3 µg x 10^6 cells, Immunohistochemistry (Paraffin): 1:50, Immunoprecipitation: 2 µg/mL, Western Blot: 0.5-1.0 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | p53 Antibody Cocktail. The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. p53 |
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| Immunogen | n/a |
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| Other Names | antigen NY-CO-13, cellular tumor antigen p53, p53 tumor suppressor, phosphoprotein p53, transformation-related protein 53, TP53 |
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| Gene, Accession # | Entrez: 22059, 7157, 716170; Uniprot: P02340, P04637, P56424 |
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| Catalog # | MA5-14067 |
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| Price | |
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| Order / More Info | p53 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 10940505, 11782364, 12522004, 12682632, 12765416, 12834749, 12844233, 12919956, 13679208, 14506735, 14738320, 14997499, 14999779, 15140542, 15196999, 15229249, 15260857, 15342377, 15381086, 15467455, 15468998, 15489653, 15657348, 15982302, 15992918, 16080465, 16084457, 16343436, 16413663, 16426421, 16439685, 16546135, 16614520, 16688362, 16787530, 16804906, 16810543, 16824077, 16936710, 17295649, 17352244, 17397945, 17408702, 17413990, 17581415, 17624738, 17641794, 17668440, 17724798, 17882495, 17947469, 18245538, 18388863, 18608579, 18802665, 19035275, 19189638, 19434317, 19527492, 19577853, 19815839, 19846940, 20063202, 20108544, 20122174, 20214740, 20230646, 20427035, 20881860, 20944119, 20952295, 20963646, 21060032, 21062935, 21469425, 21937381, 21997193, 22103332, 22109999, 22121263, 22221671, 22242180, 22351431, 22365624, 22589537, 22609107, 22615883, 22634494, 22693253, 22899540, 22975381, 23178935, 23270518, 23310950, 23319821, 23372829, 23410662, 23469219, 23526092, 23739040, 24001413, 24674866, 25547823, 25820592, 25906126, 26329539, 27038930, 27437774, 27651340 |
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