| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | p53 |
|---|
| Clone | DO-1 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human, rhesus monkey |
|---|
| Isotype | IgG2a |
|---|
| Format | purified |
|---|
| Size | 500 µl |
|---|
| Concentration | n/a |
|---|
| Applications | ChIP assay: 1-3 µg x 10^6 cells, Immunocytochemistry: Assay-Dependent, Immunofluorescence: Assay Dependent, Immunohistochemistry (Paraffin): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | p53 Monoclonal Antibody (DO-1). The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilizat |
|---|
| Immunogen | n/a |
|---|
| Other Names | antigen NY-CO-13, cellular tumor antigen p53, p53 tumor suppressor, phosphoprotein p53, transformation-related protein 53, TP53 |
|---|
| Gene, Accession # | Entrez: 7157, 716170; Uniprot: P04637, P56424 |
|---|
| Catalog # | AHO0152 |
|---|
| Price | |
|---|
| Order / More Info | p53 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | PubMed: 18538737, 22013048, 23554916, 24751483, 24804557, 26341722, 26456302, 27602106, 27899422, 28356953 |
|---|
| 产品资料 |
|
|