| 产品详情 |
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| Antigenic Specificity | c-Abl |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1:50-1:100, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | c-Abl Polyclonal Antibody. c-Abl (Abelson murine leukemia viral oncogene homolog 1, ABL1) is a 140 kDa proto-oncogene member of the Src family of non-receptor tyrosine kinases. c-Abl has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns c-Abl into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and c-Abl genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for c-Abl. In chronic myelog |
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| Immunogen | n/a |
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| Other Names | Proto-oncogene tyrosine-protein kinase ABL1, p150, c-ABL |
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| Gene, Accession # | Entrez: 25; Uniprot: P00519 |
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| Catalog # | PA5-14760 |
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| Price | |
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| Order / More Info | c-Abl Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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