| 产品详情 |
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| Antigenic Specificity | CYP17A1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | lyophilized |
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| Applications | ELISA: Assay-dependent, Immunohistochemistry (Paraffin): 2 µg/mL, Western Blot: 0.5 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CYP17A1 Polyclonal Antibody. CYP17A (17-alpha-hydroxylase/17,20-lyase) is important for the conversion of pregnenolone and progesterone to dehydroepiandrosterone (DHEA) and androstenedione. In this process, it catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. CYP17A1 is crucial during sexual development, both during fetal development and during puberty, and is intracellularly regulated by cAMP levels. Defects in the CYP17A1 gene, which encodes for the protein, may cause adrenal hyperplasia type V (AH-V) which is characterized by hypokalemia and hypertension. Male patients affected by AH-V do not undergo normal sexual differentiation and develop female external genitalia and do not undergo pubertal develoment. |
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| Immunogen | n/a |
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| Other Names | Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Gene, Accession # | Entrez: 13074, 25146; Uniprot: P11715, P27786 |
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| Catalog # | PA5-79124 |
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| Price | |
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| Order / More Info | CYP17A1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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