| 产品详情 |
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| Product Name | B-amyloid (12-28) |
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| Description | Purity >95%. ABeta (12-28) residues are the binding site for apolipoprotein E (apoE) on ABeta. This sequence encompasses a hydrophobic domain (residues 14-21) and a Beta-turn (residues 22-28) which place two hydrophobic domains of ABeta 14 to 21 and 29 to 40/42 opposite each other;allowing for the assembly of ABeta peptides into fibrils. The secondary structure of ABeta (12- 28);a neutral peptide;is dominated by a-helix and random coil. The interaction of apoE with residues 12 to 28 of ABeta is not just a non-specific hydrophobic interaction but plays a pivotal role in the mechanism of ABeta pathology in Alzheimer's disease (AD). Beta-amyloid (12-28) and five other fragments enhanced aggregation of full length ABeta (1-40). All of the peptides that enhance aggregation contained either residues 17 to 20 or 30 to 35;indicating the importance of these regions for promoting aggregation of full-length ABeta. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H4608 |
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| Price | |
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| Order / More Info | B-amyloid (12-28) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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