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| Product Name | B-Amyloid (22-35) |
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| Description | Purity >95%. Beta amyloid (22-35) is a synthetic truncated fragment of beta-amyloid peptide. It has been demonstrated that beta amyloid (22-35) possesses a cytotoxic effect on cultured rat hippocampus neurons in serum-free medium. Aggregates and typical amyloid fibrils resembling those of the beta amyloid protein (AP) are formed in neutral buffer solution from beta amyloid (22-35). These fibrils show characteristic staining with Congo red and thioflavin-S. The neurotoxicity of beta amyloid (22-35) can be suppressed by addition of calf serum;dibutyryl cAMP;or insulin to the culture medium. However;the addition of NGF or substance P will not suppress the neurotoxicity. Beta amyloid (22-35) does not act on glial cells. These results suggest that AP can induce neurotoxicity in hippocampal cells in vitro and may result in a disorder involving intracellular signal transduction. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Beta-Amyloid (22-35) |
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| Gene, Accession, CAS # | CAS: 144189-71-9 |
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| Catalog # | LS-H4457 |
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| Order / More Info | B-Amyloid (22-35) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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