| 产品详情 |
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| Antigenic Specificity | MARK1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MARK1 Polyclonal Antibody. MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be res |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | Entrez: 226778, 4139; Uniprot: Q8VHJ5, Q9P0L2 |
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| Catalog # | PA5-13945 |
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| Price | |
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| Order / More Info | MARK1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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