| 产品详情 |
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| Antigenic Specificity | Arachidonate 5-Lipoxygenase (ALOX5) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | 5-Lipoxygenase (5-LO, ALOX5) is an important catalytic enzyme responsible for the biosynthesis of leukotriene LTA4 from arachidonic acid . Leukotriene synthesis also requires 5-lipoxygenase-activating protein (FLAP, ALOX5AP), a nuclear membrane-bound protein that binds arachidonic acid and is thought to activate 5-LO. A number of related leukotrienes (i.e. B4, C4, D4) are derived from LTA4 and together these lipid mediators function in immune reaction regulation. 5-LO is primarily expressed in polymorphonuclear leukocytes, peripheral blood monocytes, macrophages, and mast cells . Overexpression of 5-LO protein is seen in certain cancer cells and is associated with poor diagnosis . Depending upon the cell type, 5-LO is localized to either the cytosol or the nucleus of quiescent cells . Following stimulation, 5-LO translocates to the nucleus and associates with FLAP to catalyze LTA4 synthesis . Phosphorylation of specific residues can regulate 5-LO enzymatic activity. Phosphorylation of 5-LO at Ser523 by PKA family kinases inhibits oxygenase activity while MAPKAP2 and ERK family kinase phosphorylation at Ser271 and Ser663 stimulates 5-LO enzymatic activity in vivo . Synonyms: 5-LO, 5-LOX, 5LPG, LOG5, MGC163204, |
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| Immunogen | Recombinant protein of human ALOX5 |
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| Other Names | si:dkey-194n13.2|lox5|5-LO|5-LOX|5LPG|LOG5|LOX5A|5LO|5LX|AI850497|F730011J02 |
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| Gene, Accession # | Gene ID: 240,11689,25290 |
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| Catalog # | ABIN1683357 |
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| Price | |
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| Order / More Info | Arachidonate 5-Lipoxygenase (ALOX5) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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