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| Antigenic Specificity | Arachidonate 5-Lipoxygenase (ALOX5) (aa 650-667), (C-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ALOX5(ARACHIDONATE 5-LIPOXYGENASE), also known as LOG5 or 5-LO(5-LIPOXYGENASE), is an enzyme that in humans is encoded by the ALOX5 gene. ALOX5 is a member of the lipoxygenase family of enzymes which also transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases. The enzyme 5-lipoxygenase catalyzes 2 reactions in the formation of leukotrienes. The ALOX5 gene is mapped to chromosome 10q11.21 based on an alignment of the ALOX5 sequence with the genomic sequence. Human 5-LO contains 3 nuclear localization sequences(NLSs) and a phosphorylation site involved in nuclear localization. Compared with age-matched 5-LO competent mice, the 5-LO knockout mice developed less right heart hypertrophy. Pharmacologic inhibition or ALOX5 gene disruption resulted in a significant decrease of beta-amyloid production and gamma-secretase levels. ALOX5 activity is short-lived, apparently in part because of an intrinsic instability of the enzyme. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human 5 Lipoxygenase(650-667aa AERNKKKQLPYYYLSPDR), different from the related rat and mouse sequences by two amino acids. |
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| Other Names | si:dkey-194n13.2|lox5|5-LO|5-LOX|5LPG|LOG5|LOX5A|5LO|5LX|AI850497|F730011J02 |
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| Gene, Accession # | Gene ID: 240 |
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| Catalog # | ABIN1673123 |
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| Price | |
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| Order / More Info | Arachidonate 5-Lipoxygenase (ALOX5) (aa 650-667), (C-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 12417634, 15931391 |
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