| 产品详情 |
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| Antigenic Specificity | CD8 beta |
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| Clone | 341 |
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| Host Species | Mouse |
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| Reactive Species | rat |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1.5 µg/mL, Functional Assay: Assay Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD8 beta Monoclonal Antibody (341). The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages, mast cells, and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversit |
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| Immunogen | n/a |
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| Other Names | Cd8b1, CD8 antigen 37 kDa chain, CD8 antigen beta-chain, CD8 antigen beta chain, OX-8 membrane antigen, T-cell surface glycoprotein CD8 beta chain |
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| Gene, Accession # | Entrez: 24931; Uniprot: P05541 |
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| Catalog # | MA1-10306 |
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| Price | |
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| Order / More Info | CD8 beta Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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