| 产品详情 |
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| Antigenic Specificity | HAP1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 20 µg/mL, Immunofluorescence: 20 µg/mL, Immunohistochemistry: 2.5 µg/mL, Western Blot: 0.5-1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | HAP1 Polyclonal Antibody. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, whi |
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| Immunogen | n/a |
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| Other Names | HAP2, HIP5, HLP, hHLP1; HAP-1; huntingtin-associated protein 2; neuroan 1 |
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| Gene, Accession # | Entrez: 15114, 29430, 9001; Uniprot: O35668, P54256, P54257 |
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| Catalog # | PA5-20377 |
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| Price | |
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| Order / More Info | HAP1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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