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| Antigenic Specificity | FEN1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:10-1:50, Immunofluorescence: 1:100, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | FEN1 Polyclonal Antibody. FEN1 removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. This protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. T |
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| Immunogen | n/a |
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| Other Names | Flap endonuclease 1; Flap structure-specific endonuclease 1; Maturation factor 1; DNase IV; RAD2 |
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| Gene, Accession # | Entrez: 2237; Uniprot: P39748 |
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| Catalog # | PA5-12480 |
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| Price | |
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| Order / More Info | FEN1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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